Researchers from the Technion have developed a technology that replaces scalpels with natural biological materials. This allows orthodontic surgeries with an enzymatic blade and without necessary incision.
In an article recently published in ACS Nano, researchers describe the application of this technology in a surgical procedure in the oral cavity.
The application avoids the pain associated with orthodontic surgeries when you go to a dentist in Tijuana Mexico and significantly reduces the recovery time of the tissue.
The new technology is based on the rational use of enzymes: biological molecules that the body uses to repair itself, as well as the use of nanoparticles to achieve a specific therapeutic profile.
In the United States alone, approximately 5 million people undergo orthodontic treatment each year.
To accelerate the treatment, which usually lasts about two years, many undergo invasive surgeries, in which the collagen fibers that connect the tooth to the underlying bone tissue are cut.
The technology developed in the Technion softens the collagen fibers through the selective release of collagenase, an enzyme that specifically breaks down collagen.
As long as the collagenase particles are packed in the liposome, they will be inactive.
But with this special nanotechnology, an ointment is applied at the target site, so that the enzyme begins to gradually filter out from the liposome and softens the collagen fibers.
The researchers conducted a series of tests to determine the optimal collagenase concentration for the procedure and to accelerate tissue repair thereafter.
In a preclinical trial, the researchers compared the effectiveness of the controlled-release system (in combination with orthopedic appliances) with that of standard orthodontic treatment and concluded that the system reduces the time required to straighten the teeth and improve the therapeutic outcome.
This would result in an orthodontic treatment in humans that lasts several months, instead of two years. The researchers estimate that it could be used in humans within a couple of years.
While the ACS Nano article presents a specific application of the “enzymatic sheet” in the field of orthodontics, the researchers emphasize that the new paradigm can be applied in a variety of surgical procedures.
For thousands of years, the surgical knife has been updated, however, the general paradigm has not changed.
Here, in the current study, we present a considerable paradigm shift: replace the metal sheet with a biological process.